Trace Amine Associated Receptor 8 (TAAR8)

G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Borowsky et al. (2001) identified GPR102, which they designated TA5, by PCR of human placenta genomic DNA using degenerate primers designed from a portion of a 5HT receptor. By quantitative RT-PCR, they found GPR102 mRNA expressed in kidney and amygdala and not in other tissues or brain regions tested. Lee et al. (2001) identified GPR102 in a genomic database using sequences of the histamine receptor H4 as query. PCR primers were designed to amplify and clone GPR102 from a genomic library. Full-length GPR102 encodes a deduced 342-amino acid protein that shares 35 to 42% sequence identity in the transmembrane regions with the G protein-coupled receptors PNR and GPR58 .