Transducin Beta like 1, X-Linked Receptor 1 (TbL1XR1)

TBL1XR1 has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.The 3-prime UTR of TBLR1 is more than 2 kb long. The deduced 515-amino acid TBLR1 protein contains 4 WD40 repeats and shares significant identity with TBL1. Northern blot analysis detected transcripts of 4.3 and 7.8 kb in several tissues, including leukemic cells. RNA dot blot analysis detected widespread expression.