Arginine Vasopressin Receptor 1B (AVPR1B)

Arginine vasopressin receptor 1B (AVPR1B, previously known as vasopressin 3 receptor or antidiuretic hormone receptor 1b) is a protein that acts as receptor for arginine vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary, where it stimulates ACTH release. Subsequent studies have shown that it is also present in the brain.The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsters and anti-depressant- and anxiety (anxiolytic)-like behaviors in rats.