C-Type Lectin Domain Family 6, Member A (CLEC6A)

CLEC6A is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain.The predicted 209-amino acid protein shares 68% identity with mouse dectin-2. It has a short N-terminal cytoplasmic region that lacks a tyrosine-based signaling motif, a 27-residue transmembrane domain with a charged arginine, and a C-terminal extracellular portion with 6 cysteines predicted to form a carbohydrate recognition domain. RT-PCR analysis revealed strong expression in lung and weak expression in spleen, lymph node, and blood leukocytes. Among in vitro-generated dendritic cells (DCs), expression of dectin-2 was strongest in immature Langerhans cell (LC)-type DCs.