Calcitonin Receptor (CTR)

The calcitonin receptor (CT) is a G protein-coupled receptor which binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism .CT works by activating the G-proteins Gs and Gq, The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY1 (CT+RAMP1), AMY2 (CT+RAMP2), and AMY3 (CT+RAMP3). A cell line had been shown to respond to calcitonin (CT, or CALCA) with increases in content of cellular cAMP. Transfection of this cDNA into COS cells resulted in expression of receptors with high affinity for salmon and human calcitonin. The expressed CALCR was coupled to adenylate cyclase.