Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3)

The deduced 469-amino acid protein has the characteristic 7-transmembrane domain structure of a G protein-coupled receptor, as well as 2 putative N-glycosylation sites in its N-terminal domain. SALPR shares highest sequence similarity with somatostatin receptors and angiotensin receptors. SALPR expression was not detected by Northern blot analysis. RT-PCR detected SALPR expression predominantly in brain, with highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus, and corpus callosum; expression was very low in cerebellum. In peripheral tissues, relatively high expression was detected in adrenal gland, and low expression was detected in pancreas, salivary gland, placenta, mammary gland, and testis. Little to no expression was detected in other tissues examined.