17-Beta-Hydroxysteroid Dehydrogenase Type 11 (HSD17b11)

Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones. The deduced 300-amino acid protein has a potential N-glycosylation site at residue 228. The 5-prime UTR of the cDNA has a polymorphic adenosine repeat. high 17-beta-HSDXI expression in pancreas, kidney, liver, lung, adrenal gland, ovary, and heart. strong expression in steroidogenic cells, such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. Expression in fetal adrenal gland increased after birth.In the eye, PAN1B was detected in nonpigmented epithelium of the ciliary body, with lower expression in the inner nuclear layer of the retina. Expression was also detected in normal adrenal cortex, granulosa cells, paraluteal cells, Leydig cells, and syncytiotrophoblasts.