2,4-Dienoyl Coenzyme A Reductase 1 (DECR1)

2,4-Dienoyl-CoA reductase (EC 1.3.1.34) is an auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Helander et al. (1997) described the molecular cloning of the human gene for the 120-kD isoform of mitochondrial 2,4-dienoyl-CoA reductase (DECR1). DECR1 gene is approximately 30 kb and comprises 10 exons varying in size from 79 to 203 bp and 9 introns whose sizes vary from 95 bp to about 10 kb. The 5-prime UTR and 3-prime UTR are included in exons 1 and 10, respectively. The promoter region contains putative binding sites for several transcription factors but no TATA box. Variability in the length of the 5-prime UTR was found, the longest being 72 bp.