2",5"-Oligoadenylate Synthetase Like Protein (OASL)

The thyroid hormone receptors (TRs) are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. In a screen for TR-interacting proteins (TRIPs), The predicted 514-amino acid p59OASL shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. Northern blot analysis revealed that p59OASL is expressed in most tissues, with the highest levels in primary blood leukocytes and other hematopoietic system tissues, colon, and stomach. p59OASL transcription is induced by interferon. The p59OASL gene contains 6 exons. Exons 1-5 are similar in structure to exons 3-7 of OAS1, suggesting that the 2 genes arose from a duplication of an ancestral gene.