3-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD3b1)

The HSD3B1 gene encodes the type I enzyme, which is expressed mainly in the placenta and peripheral tissues. human HSD3B1 and HSD3B2 have 93.6% sequence identity, including the 5-prime and 3-prime untranslated regions. HSD3B subtype-specific quantitative RT-PCR analysis of mouse adrenal gland tissue revealed that expression of mouse Hsd3b6, which is the functional counterpart of HSD3B1, was considerably enriched in the aldosterone-producing zona glomerulosa cells of the adrenal gland, whereas expression of mouse Hsd3b2, which is the functional counterpart of HSD3B2, was predominantly expressed in zona fasciculata cells.HSD3B1 and HSD3B2 genes are located within a restriction fragment of approximately 290 kb.