3-Hydroxyacyl Coenzyme A Dehydrogenase 3 (HACD3)

B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts. The human homologue of this transcript contains an open reading frame that codes for a protein of 370 amino acids without known functional motifs. In transfected cells, the B-ind1 protein has been found to potentiate different effects of the small GTPase Rac1, such as c-Jun N-terminal kinase activation and transcriptional activity of nuclear factor kappaB (NF-kappaB).B-ind1 forms complexes with the constitutively activated Rac1 protein. Interestingly, the fragment encoding the median region of human B-ind1 acted as a dominant-negative variant to block Rac1-mediated NF-kappaB activity. These data define B-ind1 as a novel component of Rac1-signaling pathways leading to the modulation of gene expression.