5"-Nucleotidase, Cytosolic II (NT5C2)

5""" nucleotidases cleave off the phosphate from the 5""" end of the sugar moiety. They can be classified into various kinds depending on their substrate preferences and subcellular localization. Membrane bound 5""" nucleotidases displays specificity towards adenosine monophosphates and are predominantly involved in the salvage of preformed nucleotides and in signal transduction cascades involving purinergic receptors.Purine 5-prime-nucleotidase (EC 3.1.3.5) preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides, and is allosterically activated by various compounds, including ATP. NT5C2 is exclusively located in the cytoplasmic matrix of cells and may have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases.