6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1 (PFKFB1)

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.Fructose 2,6-P(2), an important allosteric activator of phosphofructokinase and glycolysis in liver and possibly in other tissues, is synthesized and degraded by a bifunctional enzyme, fructose 6-P,2-kinase:fructose 2,6-bisphosphatase .