6-Phosphogluconolactonase (PGLS)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone, which is the second step of the pentose phosphate pathway. The bacterial devB gene, which is often found in proximity to the glucose-6-phosphate dehydrogenase gene, encodes a protein that is homologous to the C-terminal part of human hexose-6-phosphate dehydrogenase (H6PD). Collard et al. (1999) identified PGLS cDNAs. They isolated a human liver cDNA containing a complete PGLS coding sequence. The deduced 258-amino acid PGLS protein has a calculated molecular mass of 27,529 Da. PGLS shares 33 to 37% amino acid sequence identity with yeast Sol1 to Sol4, 26% identity with the C-terminal part of human H6PD, 20 to 25% identity with bacterial devB proteins, and 17% identity with human glucosamine-6-phosphate isomerase.