A Disintegrin And Metalloprotease 18 (ADAM18)
Английские синонимы
tMDCIII, ADAM27; Disintegrin and metalloproteinase domain-containing protein 18; Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
ADAM18 encodes a member of the ADAM family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Furthermore, polyclonal antisera raised against human recombinant tMDC III demonstrated the presence of mature protein on human sperm. In common with orthologues from other species, human tMDC III contains a putative integrin-binding glu-cys-asp (ECD) motif, the relevance of which is discussed in the context of a possible role in oolemma binding.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
