ATPase Type 13A3 (ATP13A3)

ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B and ATP7A.The deduced 701-amino acid protein has a predicted molecular mass of 77.31 kD and contains an E1-E2 ATPase domain, a hydrolase domain, 3 predicted transmembrane domains, and a highly conserved ATPase phosphorylation site. ATP13A3 shares 46% identity with human ATP13A2. Northern blot analysis detected upregulated expression of AFURS1 in senescent kidney parenchymal cells compared to exponentially growing cells.ATP13A3 gene contains 18 exons. They suggested that the very long 5-prime UTR may form a secondary structure that mediates translational regulation.