AarF Domain Containing Kinase 2 (ADCK2)

ADCK2 belongs to the ADCK family, ADCK proteins possess the conserved protein-kinase motifs corresponding to regions required for ATP binding and for phosphotransfer reaction but do not conserve all of the usual kinase motifs. The ADCK family comprises five paralogs in human (ADCK1-5).  In contrast, ADCK1, 2, and 5 have split from ADCK3 and 4 very early during evolution because all eukaryotes and several, but not all, gram-negative bacteria possess at least one representative of each subgroup. Yeast ABC1/Coq8 is the ortholog of ADCK3 and 4, whereas bacterial UbiB is more similar to the ADCK1–ADCK5 subgroup. The “universal core” of ADCKs comprises a highly conserved lysine that binds the alpha phosphate and two highly conserved aspartates that bind the magnesium ions chelated by ATP.