Abhydrolase Domain Containing Protein 2 (ABHD2)

ABHD2 encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein.The protein has a central core predicted to form alpha/beta hydrolase folds and has a ser-ala-his catalytic triad characteristic of peroxidases. By database analysis, the authors identified human ABHD2, which encodes a deduced 425-amino acid protein that shares 99% amino acid identity with mouse Abhd2. Real-time PCR detected Abhd2 in all adult mouse tissues examined, with highest expression in testis. Abhd2 was also expressed at all embryonic stages examined.