Abhydrolase Domain Containing Protein 6 (ABHD6)

Abhd6 gene is located on chromosome 3p14.3. The 2364 cDNA sequence has an ORF which encodes a 337 residue protein, from which 98-322 amino acid is an ABH domain. The amino sequence of human ABHD6 was highly homologous to mouse ABHD6 protein. Human ABHD6, similar to mouse ABHD6, was predicted to be a lipase involved in the process of aromatic compound metabolism. But so far, there is no direct evidence showing functional similarities between human and mouse Abdh6 genes. SAGE analysis showed that in tissues like bone marrow, brain, and liver, expression of Abhd6 have relatively sharp differences between normal tissue and its corresponding cancer. Abhd6 showed relatively close phylogenetic relationship with Abhd4 and Abhd5, who were lipases involved in regulation of neutral lipid metabolism.