Acetyl Coenzyme A Carboxylase Beta (ACACb)

ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms.The predicted 2,458-amino acid ACC-beta protein contains a unique, approximately 200-amino acid sequence at its N terminus that may be related to the role of ACC-beta in controlling carnitine palmitoyltransferase I activity and fatty acid oxidation by mitochondria. Excluding this unique N-terminal sequence, ACC-alpha and -beta share about 75% amino acid identity. All of the functional domains of ACC are found in homologous regions of the proteins. The approximately 10-kb ACC-beta mRNA was primarily expressed in heart and skeletal muscle tissues. In contrast, ACC-alpha mRNA was detected in all tissues tested.