Acyl Coenzyme A Dehydrogenase Family, Member 10 (ACAD10)

ACAD10 encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. The deduced 1,059-amino acid protein has a predicted molecular mass of 118.8 kD and contains a conserved acyl-CoA dehydrogenase domain extending from amino acids 655 through 1056. RT-PCR analysis detected ACAD10 mRNA in a wide range of tissues, with high expression in liver, kidney, pancreas, and spleen.