Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9)

Mitochondrial fatty acid beta-oxidation is one of the main energy-producing metabolic pathways in eukaryotes. Acyl-CoA dehydrogenases (ACADs; EC 1.3.99.13) are mitochondrial enzymes that catalyze the initial rate-limiting step in the beta-oxidation of fatty acyl-CoA. ACAD9 belongs to a group of ACADs that act on fatty acids containing 14 to 20 carbons.The deduced 621-amino acid protein has a calculated molecular mass of 68.8 kD. It has an N-terminal leader sequence, 2 conserved motifs shared by all ACAD family members, and a potential N-glycosylation site. Northern blot analysis detected a 2.6-kb transcript in all tissues examined except peripheral blood leukocytes. ACAD9 is the long-chain acyl-CoA dehydrogenase in human embryonic and fetal brain and central nervous tissue.