Acyl Coenzyme A Synthetase Long Chain Family, Member 6 (ACSL6)

Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA.The deduced 697-amino acid protein has a calculated molecular mass of 77.6 kD. It has a transmembrane region and a predicted extended cytoplasmic tail of 657 amino acids. Northern blot analysis detected variable expression of 2.9- and 6.3-kb transcripts in K562 cells, fetal blood derived from liver cells, reticulocytes, bone marrow, and cord blood. LACS5 was also expressed in human brain as transcripts of 9.4 kb and 2.9 kb. Western blot analysis of human erythrocyte ghosts detected LACS5 at an apparent molecular mass of 78 kD.very high ACSL6 expression in whole adult brain and in all specific adult brain regions examined.