Acyl Coenzyme A Thioesterase 11 (ACOT11)

ACOT11 encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms. The longer variant, designated BFIT1, encodes a 607-amino acid protein, and the other, BFIT2, differs in the C terminus and encodes a 594-amino acid protein. Both variants contain 2 acyl-CoA thioesterase domains and a lipid-binding domain. BFIT2 appears to be the ortholog of mouse Bfit.