Acyl Malonyl Condensing Enzyme 1 Like Protein 1 (AMAC1L1)

AMAC1 (acyl-malonyl condensing enzyme 1), also known as TMEM21A (transmembrane protein 21A), is a 338 amino acid multi-pass membrane protein that contains two DUF6 domains and is highly expressed in testis.AMAC1L1, AMAC1L2 and AMAC1L3 are acyl-malonyl condensing enzyme 1-like proteins that, similar to AMAC1, contain DUF6 domains and are present in tissues such as placenta and testis. Human AMAC1 and AMAC1L3 are encoded by genes which map to chromosome 17, while human AMAC1L1 and AMAC1L2 are encoded by genes that map to chromosomes 18 and 8, respectively. Together, chromosomes 8, 17 and 18 encode over 2,300 genes, some of which include the tumor suppressors p53 and BRCA1, as well as genes that are associated with Edwards syndrome, Niemann-Pick disease, Pfeiffer syndrome and congenital hypothyroidism.