Adenosine Deaminase, tRNA Specific 1 (ADAT1)

ADAT1 is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. this predicted 502-amino acid protein """adenosine deaminase acting on tRNA,""" or ADAT1, and concluded that it probably represents the human counterpart of the yeast protein Tad1p. Southern blot analysis revealed that the ADAT1 enzyme is represented by a single gene. Northern blot analysis detected ADAT1 transcripts of approximately 5 and 6.5 kb in all human tissues, with highest expression levels in heart, brain, and pancreas.