Adenosine Deaminase, tRNA Specific 3 (ADAT3)

Adenosine Deaminase,tRNA-Specific 3(ADAT3) belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.May be involved in deamination of adenosine-34 to inosine in many tRNAs as a regulatory subunit (Potential).Phosphorylated upon DNA damage, probably by ATM or ATR.Val-225 is present instead of the conserved Glu which is an active site in the cytidine and deoxycytidylate deaminase family of enzymes. It is suggested that this protein may act as a regulatory subunit.The mammalian RNA-specific adenosine deaminases (ADARs) constitute a family of sequence-related proteins involved in pre-mRNA editing of nuclear transcripts through site-specific adenosine modification. Maas et al. (1999) identified and characterized a human ADAR-related protein that specifically deaminates adenosine-37 to inosine in eukaryotic tRNA(ala).