Aldo Keto Reductase Family 1, Member C Like Protein 1 (AKR1CL1)

AKR1CL1 is located between AKR1C3 and. No additional ESTs that would represent AKR1CL1 or other AKR1C genes were identified by sequence similarity analyses. Because of the high homology of these genes to all of the human AKR1C genes they were named by their relative position and conservation of amino acid sequence with human genes. The identity of pig AKR1CL2 could be confidently assigned; pig AKR1CL2 was most similar to human AKR1CL2 and mouse Akr1e1 and had little similarity to other human AKR1C genes. The pig AKR1C1 followed by AKR1C2 was the most similar to human AKR1C genes (83–85%) and to bovine AKR1C genes; pig AKR1C4 was more closely related to human AKR1C4 and AKR1CL1. Except for AKR1CL2, paralogues were more similar within species than were homologues among species. Sequences corresponding to AKR1CL1 were not found in BAC subclones.