Anaphase Promoting Complex Subunit 1 (ANAPC1)

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.The deduced protein contains a repetitive region with at least 4 repeat domains predicted to fold into successive alpha/beta elements and form a horseshoe-like structure. Flanking the repetitive region are 2 Pfam-B domains. Mouse and human ANAPC1 share 92% amino acid identity, including 99% identity within the repetitive region. Northern blot analysis detected ANAPC1 expression in most tissues and cancer cell lines examined.