Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3C (APOBEC3C)

APOBEC3C is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22.The deduced 190-amino acid protein shares the overall domain structure of APOBEC1, including an active site, a linker region, and a pseudoactive site, but it lacks the N-terminal alpha helix. Northern blot analysis detected moderate to high expression in spleen, testis, peripheral blood leukocytes, heart, thymus, prostate, and ovary. Moderate to low expression was found in other tissues, including colon. APOBEC3C was expressed at high levels in colorectal adenocarcinoma and chronic myelogenous leukemia cells, and to a lesser extent in several other lymphoma and leukemia cell lines.