Arachidonate-12-Lipoxygenase (ALOX12)

Arachidonate 12-lipoxygenase introduces a molecular oxygen into the C-12 position of arachidonic acid to produce 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid. The major pathway of arachidonic acid metabolism in human platelets proceeds via a 12-lipoxygenase enzyme. Expression of the LOG12 gene was detected in human erythroleukemia cells, platelets, and human umbilical vein endothelial cells by reverse transcription-PCR analysis. The presumed pseudogene showed no detectable expression in several tissues and cell lines. Arachidonate 12-lipoxygenase introduces a molecular oxygen into C-12 of arachidonic acid. The enzyme is present also in leukocytes and has been found in various mammalian tissues such as porcine and bovine leukocytes, murine eosinophils, bovine tracheal cells, and porcine pituitary cells.