Arylsulfatase J (ARSJ)

Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules.the deduced 596-amino acid protein has a predicted molecular mass of 67 kD and identified a splice variant that encodes a protein in which the C-terminal 10 amino acids are replaced with 7 different amino acids. high expression of an approximately 4.4-kb transcript in fetal kidney, with lower expression in fetal lung and 2 human cancer cell lines. No expression was detected in any normal adult tissues examined. ARSJ detected the protein in both the soluble and particulate fractions, suggesting a portion of ARSJ associates with cellular organelles or membrane structures.