Asparaginyl tRNA Synthetase 2, Mitochondrial (NARS2)

By searching databases for aminoacyl-tRNA synthetases containing a mitochondrial targeting sequence, Bonnefond et al. (2005) identified NARS2, which the called mitochondrial ASNRS. The deduced 477-amino acid protein has an N-terminal mitochondrial targeting signal with a predicted cleavage site after residue 14. NARS2 has characteristics of a class II mitochondrial aminoacyl-tRNA synthetase and is expected to function as a dimer.Bonnefond et al. (2005) determined that the NARS2 gene contains 14 exons and spans 137.8 kb.By genomic sequence analysis, Bonnefond et al. (2005) mapped the NARS2 gene to chromosome 11.