Aurora Kinase C (AURKC)

Serine/threonine-protein kinase 13 is a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.mouse Aie1 (Aurora/Ipl1/EG2-1) and human STK13, which they designated AIE2. Both Aie1 and AIE2 contain a central serine/threonine kinase domain. The authors reported that AIE2 contains 309 amino acids. Northern blot analysis detected expression of a 1.35-kb AIE2 mRNA only in testis.