CTD Small Phosphatase Like Protein 2 (CTDSPL2)

CTDSPL2 gene can obviously improve the expression of ε- and γ-globin genes in K562 cells and CD34+ cells derived from UCB. Expression levels of the CTD small phosphatase like 2 (CTDSPL2) gene were higher in UCB than in healthy adult BM. CTD phosphatase dephosphorylates the CTD tail of the largest subnit of RNA polymerase II (RNAPII). CTDSPL2 had higher expression levels in erythroid cultures derived from UCB than from healthy adult BM.CTDSPL2 had higher expression levels in erythroid cultures derived from UCB than from healthy adult BM. Differential expression of CTDSPL2 was also detected by real-time PCR. Expression levels of CTDSPL2 mRNA in UCB erythroid cultures were 2.6 times greater than in healthy adult BM erythroid cultures.