Cardiolipin Synthase (CLS)

By analysis of a BAC clone containing the MCM8 gene , Johnson et al. (2003) identified a novel gene they designated GCD10 due to homology between the deduced protein and S. cerevisiae Gcd10, an RNA-binding protein. EST analysis indicated that GCD10 has several putative start sites and 2 alternatively spliced transcripts. Johnson et al. (2003) determined that the GCD10 gene contains 11 exons, spans 12.7 kb, and lies in a head-to-head orientation with the MCM8 gene. The 5-prime untranslated region, which is shared with MCM8, contains a CpG island and a putative CCAAT element that is less than 30 bp from the GCD10 start point, but lacks TATA boxes for either gene. There are putative binding sites for SP1, ETS1 (164720), E2F1, and PURA .