Carnitine-O-Octanoyltransferase (CORT)

Carnitine octanoyltransferase is a carnitine acyltransferase that catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine. This provides a crucial step in the transport of medium- and long-chain acyl-CoA out of the mammalian peroxisome to the cytosol and mitochondria. CROT shares 85% sequence identity with both the bovine and rat CROT proteins.CROT efficiently converts a branched-chain fatty acyl-CoA (4,8-dimethylnonanoyl-CoA) to its corresponding carnitine ester. CROT plays a crucial role in the beta-oxidation of branched-chain fatty acids including pristanic acid.CROT gene contains 18 exons spanning 54 kb of genomic DNA.COT efficiently converts one of the end products of the peroxisomal beta-oxidation of pristanic acid, 4, 8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.