Carnitine Palmitoyltransferase 1C, Brain (CPT1C)

Mitochondrial fatty acid oxidation is controlled by carnitine palmitoyltransferase I (CPT1), which is tightly regulated via its inhibition by malonyl-CoA. For background information on this process. By EST database searching with the liver-specific CPT1A sequence as query, Price et al. (2002) identified a full-length cDNA sequence for human and mouse CPT1C. Northern blot analysis showed high levels of a 2.8-kb CPT1C transcript in brain, lower levels in testis and ovary, and very low levels in small intestine and colon. In situ hybridization showed low levels of Cpt1c expression throughout mouse brain, and very high levels of expression in hippocampus and the paraventricular, arcuate, and superchiasmatic nuclei. Western blot analysis showed CPT1C in both mitochondrial and microsomal fractions from mouse brain.