Casein Kinase 1 Alpha 1 (CSNK1a1)

Casein kinase activity was found to be present in most cell types and to be associated with multiple enzymes. The type 1 casein kinase family of related gene products are now given designations such as "casein kinase 1 alpha" and "casein kinase 1 epsilon". Casein kinase 1 alpha has been suggested to play a role in phosphorylation of Disheveled in the Wnt signaling pathway .Jia et al. (2004) showed that protein kinase A (PKA) and casein kinase I (CKI) regulate Smo cell surface accumulation and activity in response to hedgehog (Hh). Blocking PKA or CKI activity in the Drosophila wing disc prevented Hh-induced Smo accumulation and attenuated pathway activity, whereas increasing PKA activity promoted Smo accumulation and pathway activation.