Casein Kinase 1 Alpha 1 Like Protein (CSNK1a1L)

CSNK1A1L, Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Contains 1 protein kinase domain. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.Casein kinase 1 alpha has been suggested to play a role in phosphorylation of Disheveled in the Wnt signaling pathway .Jia et al. (2004) showed that protein kinase A (PKA) and casein kinase I (CKI) regulate Smo cell surface accumulation and activity in response to hedgehog (Hh). Blocking PKA or CKI activity in the Drosophila wing disc prevented Hh-induced Smo accumulation and attenuated pathway activity, whereas increasing PKA activity promoted Smo accumulation and pathway activation.