Casein Kinase 1 Gamma 3 (CSNK1g3)

The casein kinase I (CKI) gene family encodes serine/threonine kinases that preferentially phosphorylate acidic substrates using ATP as a phosphate donor. CKI proteins are monomeric and range from 25 to 55 kD. They are ubiquitous, being found in the nuclei, cytoplasm, and membrane fractions of eukaryotic cells.The deduced 447-amino acid CSNK1G3 protein shares 98% sequence identity with rat CKI gamma-3. The authors also isolated a cDNA whose sequence is identical to that of the aforementioned CSNK1G3 cDNA except that it contains a 24-bp insertion in the coding sequence and an 8-bp insertion in the 3-prime untranslated region. They suggested that this cDNA represents an alternatively spliced CSNK1G3 transcript, which they named CSNK1G3L.