Coactivator Associated Arginine Methyltransferase 1 (CARM1)

CARM1 (coactivator-associated arginine methyltransferase 1) is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals.CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts. This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.The central portion of the coding region had extensive homology to a family of proteins with arginine-specific protein methyltransferase activity. The protein, coactivator-associated arginine methyltransferase-1 (CARM1), has a 3.8-kb mRNA that is widely but not evenly expressed in adult mouse tissues.