Cyclin Dependent Kinase Like Protein 3 (CDKL3)

CDKL3 is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. The deduced 455-amino acid protein contains the MAPK-like TDY motif for threonine and tyrosine phosphorylation, as well as the putative cyclin-binding motif. NKIAMRE shares 84% amino acid identity with rat Nkiatre and 41% and 42% identity with human KKIAMRE (CDKL2) and KKIALRE (CDKL1), respectively.