Cytochrome P450 2U1 (CYP2U1)

CYP2U1 encodes a member of the cytochrome P450 superfamily of enzymes. CYP2U1 metabolized arachidonic acid, docosahexaenoic acid (DHA), and other long chain fatty acids which suggests that CYP2U1 may play a role in brain and immune functions. CYP2U1 also metabolizes propanone, acetone and 2-oxypropane.The protein shares many of the hallmark features of members of the cytochrome P450 family, including a heme binding domain, PERF domain, and ETLR domain. The protein is highly conserved among species and shares 36% and 37.1% sequence identity with CYP2J2, an arachidonic acid (AA) epoxygenase, and CYP2R1, a microsomal vitamin D-25 hydrolase, respectively. CYP2U1 mRNA was expressed at highest levels in thymus and cerebellum, and at low levels in several other tissues tested.