Cytochrome P450 4A11 (CYP4A11)

CYP4A11 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.The CYP4A11 cDNA encodes a predicted 519-amino acid protein with a calculated molecular mass of 59.4 kD. The deduced sequence of residues 5 through 25 was identical to the N-terminal amino acid sequence of purified P450HL-omega, except for 1 undetermined residue. Baculovirus-mediated expression of the CYP4A11v cDNA yielded an unstable protein that did not efficiently metabolize lauric acid.