Cytochrome P450 4F2 (CYP4F2)

CYP4F2 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.The CYP4F2 gene contains at least 13 exons, with its open reading frame being encoded from exon II to exon XIII. Exon I includes 49 bp of a 5-prime untranslated sequence. The structure of this gene was found to be very similar to that of CYP4F3.