Cytochrome P450 4V2 (CYP4V2)

The CYP4V2 gene contains 11 exons spanning 19 kb. The coding sequence begins in exon 1 and continues through exon 11.The predicted transmembrane segment of CYP4V2 resides near the N terminus, followed by a globular structural domain typical of the CYP450 family. The globular domain of CYP4V2 comprises 18 helices and beta structural segments.PCR of human tissue-specific cDNA showed expression of CYP4V2 in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium, and lymphocytes. Highest expression was found in retina. The expression of CYP4V2 in a wide variety of tissues is consistent with inclusions and their clinical sequelae found in the cornea, retina, and lymphocytes.