Dehydrogenase/Reductase SDR Family, Member 4 (DHRS4)

By RT-PCR and RACE of a HeLa cell cDNA library, Song et al. (2007) cloned full-length NRDR and a variant lacking exon 3, which they called NRDRB1. The deduced NRDR and NRDRB1 proteins have calculated molecular masses of 29 and 27 kD, respectively. Song et al. (2007) detected NRDRB1 mRNA expression in 14 (53.9%) of 26 cervical cancer tissues, but expression was not detected in 12 normal cervical tissues. Immunohistochemical analysis detected NRDRB1 protein only in tumor tissues. The full-length NRDR mRNA was observed in both normal and neoplastic cervical tissues, but NRDR protein was only expressed in normal cervical epithelium, where it localized in peroxisomes.Fluorescence-tagged rat Dhrs4 localized to peroxisomes in transfected Chinese hamster ovary cells.