Desumoylating Isopeptidase 2 (DESI2)

PPPDE1, Belongs to the UPF0326 family. Contains 1 PPPDE peptidase domain. PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain amongst different members of the PPPDE supefamily. The presence of the PPPDE superfamily proteins in most eukaryotic lineages, including basal ones, such as Giardia, suggest a role in deubiquitination of highly conserved proteins involved in key cellular functions. PPPDE superfamily includes predicted proteases from several groups of double-stranded RNA viruses and one single-stranded DNA virus.