Diacylglycerol-O-Acyltransferase 2 Like Protein 6 (DGAT2L6)

Diacylglycerol O-Acyltransferase 2 Like Protein 6 (DGAT2L6) is a probable acyltransferase uses fatty acyl CoA as substrate. It has no wax synthase activity to produce wax esters. The esterification of alcohols such as sterols, diacylglycerols, and monoacylglycerols with fatty acids represents the formation of both storage and cytoprotective molecules. Conversely, the overproduction of these molecules is associated with several disease pathologies, including atherosclerosis and obesity. The human acyl-CoA:diacylglycerol acyltransferase (DGAT) 2 gene superfamily comprises seven members, four of which have been previously implicated in the synthesis of di- or triacylglycerol. The remaining 3 members comprise an X-linked locus and have not been characterized.